Preheat air fryer to 400 degrees Fahrenheit.
Place flour, salt, and pepper in a shallow bowl and whisk to combine.
In a second bowl, whisk the eggs and water together.
In a third bowl, mix the Panko breadcrumbs with garlic powder, onion powder, and paprika.
Dredge each chicken piece in the flour mixture, then the egg wash, and finally the breadcrumbs, pressing firmly to adhere.
Place the breaded chicken in the air fryer basket in a single layer.
Spray the surface of the chicken generously with cooking spray.
Cook for 6 minutes, flip the chicken, spray the other side, and cook for an additional 4 to 6 minutes until the internal temperature reaches 165 degrees Fahrenheit.
Remove from the air fryer and let rest for 3 minutes before serving.