Preheat the oven to 400 degrees Fahrenheit (200 degrees Celsius).
Line a 9x13 inch baking dish with parchment paper or coat lightly with cooking spray.
Pat the chicken breasts dry using paper towels to ensure optimal glaze adhesion.
In a small mixing bowl, whisk together honey, Dijon mustard, olive oil, garlic powder, onion powder, paprika, salt, and black pepper until a homogeneous glaze is formed.
Arrange the chicken breasts in a single layer in the prepared baking dish.
Using a pastry brush, coat both sides of the chicken breasts generously with the honey mustard mixture.
Place the dish in the center of the oven and bake for 25 to 30 minutes, or until the internal temperature reaches 165 degrees Fahrenheit (74 degrees Celsius) on an instant-read thermometer.
Remove from the oven and allow the chicken to rest for 5 minutes to redistribute juices before serving.