Place the cubed beef chuck roast into the basin of a 6-quart slow cooker.
In a mixing bowl, whisk together soy sauce, brown sugar, minced garlic, sesame oil, grated ginger, and red pepper flakes until the sugar is dissolved.
Pour the sauce mixture over the beef and toss to ensure all pieces are evenly coated.
Secure the lid and cook on the low setting for 6 hours.
In a small vessel, whisk cornstarch and cold water to create a smooth slurry.
Stir the slurry into the slow cooker liquid.
Cover and cook on the high setting for an additional 15 minutes or until the sauce has thickened to a coat-back consistency.
Garnish with sliced green onions and toasted sesame seeds before serving over steamed rice.