Preheat oven to 375°F (190°C).
In a large skillet over medium-high heat, brown the ground beef until fully cooked, then drain any excess fat.
Stir the marinara sauce, dried oregano, garlic powder, salt, and pepper into the beef and simmer for 5 minutes.
In a medium bowl, whisk together the blended cottage cheese, egg, and parmesan cheese until combined.
Spread 1/2 cup of the meat sauce onto the bottom of a 9x13 inch baking dish.
Place 3 lasagna noodles over the sauce.
Layer with half of the cottage cheese mixture, half of the chopped spinach, and 1/2 cup of mozzarella cheese.
Add another layer of 3 noodles, the remaining cottage cheese mixture, the remaining spinach, and 1/2 cup of mozzarella.
Top with the final 3 noodles, the remaining meat sauce, and the remaining 1 cup of mozzarella cheese.
Cover the dish with foil and bake for 30 minutes.
Remove the foil and bake for an additional 15 minutes until the cheese is golden and bubbling.
Allow the lasagna to rest for 10 minutes before slicing into 8 equal portions.