Heat a non-stick skillet over medium-high heat.
Add the ground turkey to the skillet and cook until browned, breaking it into small crumbles, approximately 8-10 minutes.
Drain any excess fat from the skillet.
Stir in the diced bell peppers and red onions, cooking for an additional 3-4 minutes until slightly softened.
Add the marinara sauce, oregano, garlic powder, and red pepper flakes, stirring to combine and heating through for 2 minutes.
Transfer the mixture to a microwave-safe or oven-safe bowl.
Layer the shredded mozzarella cheese and pepperoni slices on top of the meat mixture.
Place under a broiler for 2-3 minutes or microwave for 45-60 seconds until the cheese is melted and bubbly.
Let stand for 2 minutes before serving.