In a large mixing bowl, combine the shredded chicken, refried beans, salsa, 1 cup of the shredded cheese, cumin, chili powder, garlic powder, and salt until the filling is thoroughly incorporated.
Warm the flour tortillas in the microwave for 30 seconds to ensure they are pliable and resist tearing.
Place approximately 1/2 cup of the chicken filling in the center of each tortilla and top with a portion of the remaining shredded cheese.
Fold the left and right sides of the tortilla inward over the filling, then roll tightly from the bottom to the top to form a secure, sealed burrito shape.
Heat the vegetable oil in a deep, heavy-bottomed skillet to 365°F (185°C).
Carefully place the chimichangas into the hot oil seam-side down to seal the fold, and fry for 2 to 3 minutes per side until the shell is golden brown and crispy.
Transfer the fried chimichangas to a wire rack or paper towel-lined plate to drain excess oil.
Serve immediately while hot, garnished with sour cream, guacamole, and fresh cilantro.