Moisten the rim of a rocks glass with a lime wedge and dip into a plate of Tajín seasoning to coat evenly.
Fill a cocktail shaker halfway with ice cubes.
Add the blanco tequila, guava nectar, lime juice, triple sec, and agave nectar to the shaker.
Secure the lid and shake vigorously for 15 to 20 seconds until the exterior of the shaker is frosted.
Fill the prepared glass with fresh ice.
Strain the mixture through a Hawthorne strainer into the glass.
Garnish with a lime wheel or fresh guava slice and serve immediately.